Ton will be looking to make it seven unbeaten in all competitions in facing a Thamesmead side who currently sit fourteenth in the table, and without a League win since an opening day success at Lydd Town.
However Jason Long's side have hit a purple patch in this season's FA Vase with progress into the first round proper, after a 3-1 home victory against Southern Combination Division One outfit, Billingshurst, on Saturday - goals from Jedd Smith, Dan Edwards and Joseph Sylvester.
This followed an impressive 3-2 home victory against SCEFL rivals Sutton Athletic in the first qualifying round. They are at Bayliss Avenue for a third consecutive tie, hosting Ascot United of the Combined Counties Premier.
A brace from Gary Lockyer saw Ton take all three points in the corresponding fixture in April, last season - Merrick Simms on target for Thamesmead.